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This initiative is targeted to oncologists, oncology residents/fellows, nurse practitioners, nurses, physician assistants, pharmacists, genetic counselors, and other members of the oncology patient care team. Attendees of this Grand Rounds series will gain an appreciation of the latest clinical and scientific advances in targeting DNA damage response (DDR), including updates on the current and emerging prospects of poly (ADP-ribose) polymerase inhibitors, the most up-to-date guidelines on BRCA genetic testing and counseling, as well as case-based strategies members of the oncology patient care team can employ to improve patient outcomes.