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This Grand Rounds series is based on a tumor board model in which faculty will present patient cases and lead discussions regarding proposed treatment approaches, including appropriate sequencing and combination regimens based on the latest trial data and patient- and tumor-specific factors. The presentation will also include strategies to successfully incorporate these novel therapies into clinical practice and address barriers to their use in B-cell malignancies, including patient adherence and management of drug-associated toxicities. This Grand Rounds series will draw attendees into the process of peer discussion and encourage the promotion of collaborative exchange with other members of the oncology care team to ensure optimal patient outcomes.